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Abstract
Welcome to the third issue of Therapeutics and Clinical Risk Management. As mentioned
in my editorial to the first issue, the journal aims to publish original research
and review articles on the evidence and opinion behind new and existing therapies.
Thus, the remit of Therapeutics and Clinical Risk Management will of necessity be
a broad one, and this issue vividly illustrates this. First, there are four excellent
review articles on diverse but important areas. In the opening paper, Lacy and colleagues
have provided a comprehensive review of how the noninvasive airway sampling technique
of sputum induction may assist in the diagnosis and management of obstructive airway
diseases. This is followed by reviews of adverse drug reporting by pharmacists in
New Zealand and an update on current thinking on the vital and challenging area of
improving patient compliance. The reviews are concluded by an overview of the state
of play regarding the development of inhibitors of selectin function for novel treatment
of inflammatory disorders of the skin. This is an intriguing area with relevance for
all inflammatory conditions as selectins mediate the earliest events controlling leukocyte
extravasation into the tissues. The original research papers truly encompass a broad
church covering areas as varied as the influence of application site and formulation
on skin penetration by sunscreens; a general practitioner-based survey of how lifestyle
changes can facilitate the treatment of gastroesophageal reflux disease; liver damage
and gastrointestinal bleeding associated with neuroleptic malignant syndrome; and
examination of one aspect of the mechanisms by which thalidomide exerts its therapeutic
effect in myeloma. The final paper is a very interesting study that examines the absence
of toll-like receptor (TLR)-4 gene polymorphisms in Singaporean Chinese. This is important
as the literature on associations between TLR4 polymorphisms and asthma/allergy are
not consistent, and this paper suggests that ethnicity is an issue for studies of
this nature.
Author and article information
Journal
Journal ID (nlm-ta): Ther Clin Risk Manag
Journal ID (publisher-id): Therapeutics and Clinical Risk Management
Title:
Therapeutics and Clinical Risk Management
Publisher:
Dove Medical Press
ISSN
(Print):
1176-6336
ISSN
(Electronic):
1178-203X
Publication date
(Print):
September
2005
Publication date
(Electronic):
September
2005
Volume: 1
Issue: 3
Page: 167
Affiliations
Asthmatic and Allergic Inflammation Group, School of Medicine, University of Aberdeen UK