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      The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting.

      Annual review of immunology

      Animals, Cell Differentiation, immunology, Cell Lineage, Cell Movement, Dendritic Cells, cytology, pathology, Humans, Inflammation, metabolism, Inflammation Mediators, physiology, Lymphoid Tissue

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          Abstract

          Dendritic cells (DCs) form a remarkable cellular network that shapes adaptive immune responses according to peripheral cues. After four decades of research, we now know that DCs arise from a hematopoietic lineage distinct from other leukocytes, establishing the DC system as a unique hematopoietic branch. Recent work has also established that tissue DCs consist of developmentally and functionally distinct subsets that differentially regulate T lymphocyte function. This review discusses major advances in our understanding of the regulation of DC lineage commitment, differentiation, diversification, and function in situ.

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          Journal
          23516985
          3853342
          10.1146/annurev-immunol-020711-074950

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