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      Beauvericin and enniatin: emerging toxins and/or remedies?

      , , , , ,
      World Mycotoxin Journal
      Wageningen Academic Publishers

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          The structure op beauvericin, a new depsipeptide antibiotic toxic to

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            Beauvericin and enniatins A, A1, B and B1 in Norwegian grain: a survey

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              Functional characterization of the human multidrug transporter, ABCG2, expressed in insect cells.

              ABCG2 (also called MXR (3), BCRP (4), or ABCP (5) is a recently-identified ABC half-transporter, which causes multidrug resistance in cancer. Here we report that the expression of the ABCG2 protein in Sf9 insect cells resulted in a high-capacity, vanadate-sensitive ATPase activity in isolated membrane preparations. ABCG2 was expressed underglycosylated, and its ATPase activity was stimulated by daunorubicin, doxorubicin, mitoxantrone, prazosin and rhodamine 123, compounds known to be transported by this protein. ABCG2-ATPase was inhibited by low concentrations of Na-orthovanadate, N-ethylmaleimide and cyclosporin A. Verapamil had no effect, while Fumitremorgin C, reversing ABCG2-dependent cancer drug resistance, strongly inhibited this ATPase activity. The functional expression of ABCG2 in this heterologous system indicates that no additional partner protein is required for the activity of this multidrug transporter, probably working as a homodimer. We suggest that the Sf9 cell membrane ATPase system is an efficient tool for examining the interactions of ABCG2 with pharmacological agents. Copyright 2001 Academic Press.
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                Author and article information

                Journal
                World Mycotoxin Journal
                World Mycotoxin Journal
                Wageningen Academic Publishers
                1875-0710
                1875-0796
                November 2010
                November 2010
                : 3
                : 4
                : 415-430
                Article
                10.3920/WMJ2010.1245
                3c957c05-95e0-4810-91c1-e3e5d37444ea
                © 2010
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