11
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      New insecticidal rocaglamide derivatives and related compounds from Aglaia oligophylla.

      Read this article at

      ScienceOpenPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Organic-soluble extracts of the twigs of Aglaia oligophylla collected in Vietnam yielded four insecticidal cyclopentatetrahydrobenzofurans of the rocaglamide type including one new natural product (compound 4). Moreover, two cyclopentatetrahydrobenzopyran derivatives, belonging to the aglain and aglaforbesin types, respectively, were also isolated. The aglaforbesin derivative 6 proved likewise to be a new natural product. All isolated rocaglamide, aglain, and aglaforbesin derivatives have a characteristic methylenedioxy substituent linked to C-6 and C-7 or to C-7 and C-8, respectively. Structure elucidation of the new natural products and the determination of the absolute configuration of compound 1 by calculation of its CD spectrum with molecular dynamics simulation are described. All isolated rocaglamide derivatives exhibited strong insecticidal activity toward neonate larvae of the polyphageous pest insect Spodoptera littoralis when incorporated into an artificial diet, with LC(50) values varying between 2.15 and 6.52 ppm.

          Related collections

          Author and article information

          Journal
          J. Nat. Prod.
          Journal of natural products
          0163-3864
          0163-3864
          Apr 2001
          : 64
          : 4
          Affiliations
          [1 ] Institut für Pharmazeutische Biologie, Heinrich Heine Universität, Düsseldorf, Universitätsstrasse 1, Gebäude 26.23, D-40225 Düsseldorf, Germany.
          Article
          np000123x
          11325219
          3ca571d2-91cd-448b-8b56-70463c7cb0db
          History

          Comments

          Comment on this article