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      The Insulin-Like Growth Factor System in Kidney Diseases

      a , b , a


      S. Karger AG

      IGF-I, IGFBPs, Renal development, Chronic renal failure, Nephritic syndrome

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          The insulin-like growth factor system is intimately involved in renal development, growth, function and the pathophysiology of several disease states. Exogenous IGF-I increases GFR and RPF, perhaps mediated by nitric oxide (NO). In chronic renal failure, IGF-I, the binding proteins and their fragments decrease bioavailability. After transplantation, the levels of bioactive IGF-I increase likely due to better nutrition and increased clearance of the binding proteins and their fragments. In the nephritic syndrome, a similar mechanism may be active, in that the binding proteins and their fragments may inhibit IGF-I action.

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          Insulin-Like Growth Factor Binding Proteins: New Proteins, New Functions

          The insulin-like growth factors (IGFs), IGF binding proteins (IGFBPs), and IGFBP proteases regulate somatic growth and cellular proliferation both in vivo and in vitro. IGFs are potent mitogens whose actions are determined by the availability of free IGFs to interact with IGF receptors. IGFBPs comprise a family of six proteins that bind IGFs with high affinity and specificity and thereby regulate IGF-dependent actions. IGFBPs have recently emerged as IGF-independent regulators of cell growth. Cleavage of IGFBPs by specific proteases modulate levels of free IGFs and IGFBPs and thereby their actions. IGFBP-related proteins (IGFBP-rPs) bind IGFs with low affinity and also play important roles in cell growth and differentiation. The GH-IGF-IGFBP axis is complex and powerful. Future research on its physiology promises exciting insights into cell biology as well as therapies for diseases such as cancer and diabetes mellitus.
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            Pathophysiologic Glomerulotubular Growth Factor Link


              Author and article information

              S. Karger AG
              24 August 2001
              : 89
              : 1
              : 5-9
              Divisions of aPediatric Endocrinology and bPediatric Nephrology, Department of Pediatrics, University of Virginia Health Sciences Center, Charlottesville, Va., USA
              46035 Nephron 2001;89:5–9
              © 2001 S. Karger AG, Basel

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              Page count
              Tables: 1, References: 43, Pages: 5
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              Distinguished Scientists Lecture Series<br>Section Editors: Chan, J.C.M.; Krieg, R.J., Jr.; Scheinmann, J.I. (Richmond, Va.)


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