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      Left Ventricular Diastolic Filling Improvement Obtained by Intravenous Verapamil in Mild to Moderate Essential Hypertension: A Complex Effect

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          In order to try and evaluate through what prevailing mechanism verapamil (V) can induce an improvement in left ventricular (LV) diastolic early filling in mild to moderate essential hypertension, 43 properly classified essential hypertensives, aged 41-74 years (mean age 58.1 ± 10.3), and 20 age-matched normotensives were studied. All subjects underwent both echocardiographic evaluation and <sup>99m</sup>Tc radionuclide angiocardiography in basal conditions between 8.00 a.m. and noon, after an overnight rest. In essential hypertensives gated equilibrium angiocardiography was repeated 3 and 30 min after i.v. V (0.1-mg/kg bolus, followed by 0.005 mg/kg/min for the period of radionuclide data acquisition). Simultaneously, supine arterial pressure was measured with a cuff manometer. In 36 essential hypertensives a phono-echo evaluation was obtained, both at 3 and 30 min after V, deriving a LV isovolumetric relaxation index (IRTI). Among diastolic early filling indices, we particularly considered the ratio of peak filling rate (PFR) to peak ejection rate (PER) in order to take into account the interaction of systolic performance with LV relaxation and diastolic early filling. Three minutes after V the increase in PFR (from 2.47 ± 0.5 to 3.04 ± 0.8 EDV/s, p < 0.001) and the upwards tendency of PFR/PER were coupled with the enhancement in ejection fraction (from 61.1 ± 13.3 to 63.9 ± 13.8%, p < 0.001) and heart rate (from 70.3 ± 12.6 to 77.7 ± 12.2 b/min, p < 0.001) and with the reduction in mean arterial pressure (from 122 ± 16 to 107 ± 14 mm Hg, p < 0.001), systemic arterial resistance index (from 3,234 ± 968 to 2,432 ± 678 dyn s cm<sup>-5</sup> m<sup>2</sup>, p < 0.001) and end-systolic volume index (from 32.9 ± 17.1 to 31.5 ± 18.3 ml/m2, p < 0.02). On the contrary, 30 min after V, when systolic indices, heart rate, mean arterial pressure and systemic arterial resistance index had returned towards baseline values, PFR/PER showed a persistent improvement when compared with basal values (0.71 ± 0.12 vs. 0.63 ± 0.08, p < 0.005). No changes were observed in LV volumes and IRTI, either at 3 or 30 min. Moreover, also the pulmonary blood volume ratio was unchanged. A weak negative correlation was found between Δ% of IRTI and Δ% of PFR/PER 30 min after drug administration (r = 0.58, p < 0.05). Finally, essential hypertensives with increased LV LV Filling after i.v. Verapamil in Essential Hypertension mass and LV concentric hypertrophy showed a greater improvement in PFR/PER (from 0.66 ± 0.1 to 0.76 ± 0.2 and from 0.67 ± 0.1 to 0.77 ± 0.1, p < 0.005 for both). Our data indicate that the improvement in LV diastolic early filling in mild to moderate essential hypertension can be ascribed not only to the hemodynamic effect of the drug, but also to a primary influence on the functional abnormalities of the myocardial cells.

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          Author and article information

          S. Karger AG
          11 November 2008
          : 76
          : 1
          : 32-41
          aSecond Department of Special Medical Pathology, Second Institute of Clinical Medicine, bDepartment of Clinical Pathophysiology, Nuclear Medicine Unit, University of Florence, Italy
          174469 Cardiology 1989;76:32–41
          © 1989 S. Karger AG, Basel

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          Pages: 10
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