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      Innate Recognition of Viruses

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      Immunity

      Elsevier BV

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          Abstract

          Virus infection elicits potent responses in all cells intended to contain virus spread before intervention by the adaptive immune system. Central to this process is the virus-elicited production of type I interferons (IFNs) and other cytokines. The sensors involved in coupling recognition of viruses to the induction of the type I IFN genes have only recently been uncovered and include endosomal and cytosolic receptors for RNA and DNA. Here, we review their properties and discuss how their ability to recognize the unusual presence of atypical nucleic acids in particular subcellular compartments is used by the body to detect virus presence.

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          Author and article information

          Journal
          Immunity
          Immunity
          Elsevier BV
          10747613
          September 2007
          September 2007
          : 27
          : 3
          : 370-383
          Article
          10.1016/j.immuni.2007.08.012
          17892846
          3cf74296-4d31-47c0-82e6-fb450397ba9a
          © 2007

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