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      IL–12–Dependent, IFN–γ–Independent Experimental Glomerulonephritis

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          Abstract

          There is evidence that crescentic glomerulonephritis initiated in rodents by heterologous antibodies against the glomerular basement membrane (anti–GBM glomerulonephritis) depends on a Th1–type immune reaction. Interleukin 12 (IL–12) is crucial for the development of Th1 helper cells, and interferon gamma (IFN–γ) is a major proinflammatory product of these cells. In order to test the role of the two cytokines in anti–GBM glomerulonephritis we used mice lacking either the p40 chain of IL–12 (IL–12–/–) or the IFN–γ receptor (IFN–γR–/–). Glomerulonephritis was induced by injecting a rabbit anti–GBM serum in mice preimmunized against rabbit IgG. Glomerulonephritis was assessed on the basis of proteinuria, immunofluorescence findings and histology. IL–12–/– mice were completely protected against glomerulonephritis. In contrast, IFN–γR–/– mice were more severely affected than wild–type mice. Similarly, cutaneous delayed–type hypersensitivity, a typical Th1 response, was abolished in the IL–12–/–, mice but increased in the IFN–γR–/– mice. The data obtained in IL–12–/– mice support the view that crescentic glomerulonephritis in this model represents a Th1 response. Since IFN–γ is not required, other products of Th1 cells are likely to mediate glomerulonephritis.

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          Most cited references 5

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          Lymphocyte responses and cytokines.

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            An Interleukin (IL)-10/IL-12 Immunoregulatory Circuit Controls Susceptibility to Autoimmune Disease

            Cells of the innate immune system secrete cytokines early in immune responses that guide maturing T helper (Th) cells along appropriate lineages. This study investigates the role of cytokine networks, bridging the innate and acquired immune systems, in the pathogenesis of an organ specific autoimmune disease. Experimental allergic encephalomyelitis (EAE), a demyelinating disease of the central nervous system, is widely used as an animal model for multiple sclerosis. We demonstrate that interleukin (IL)-12 is essential for the generation of the autoreactive Th1 cells that induce EAE, both in the presence and absence of interferon γ. The disease-promoting effects of IL-12 are antagonized by IL-10 produced by an antigen nonspecific CD4+ T cell which, in turn, is regulated by the endogenous production of IL-12. This unique immunoregulatory circuit appears to play a critical role in controlling Th cell differentiation and provides a mechanism by which microbial triggers of the innate immune system can modulate autoimmune disease.
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              Imaging high-energy astrophysical sources using Earth occultation

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                Author and article information

                Journal
                KBR
                Kidney Blood Press Res
                10.1159/issn.1420-4096
                Kidney and Blood Pressure Research
                S. Karger AG
                1420-4096
                1423-0143
                2001
                2001
                24 January 2001
                : 24
                : 1
                : 27-32
                Affiliations
                aInstitute of Anatomy, University of Zürich, Switzerland Department of Immunology, University of Cape Town, Republic of South Africa
                Article
                54202 Kidney Blood Press Res 2001;24:27–32
                10.1159/000054202
                11174003
                © 2001 S. Karger AG, Basel

                Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

                Page count
                Figures: 2, Tables: 2, References: 28, Pages: 6
                Product
                Self URI (application/pdf): https://www.karger.com/Article/Pdf/54202
                Categories
                Original Paper

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