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      Correlates of Plasma Cortisol and DNA Repair in Human Peripheral Lymphocytes: Suppression of Repair in Women Taking Estrogen

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          We have examined the relationship between total plasma cortisol concentration and DNA repair capacity in human peripheral lymphocytes cultured in vitro; the data indicate that high concentrations of cortisol ( > 20 µg/dl) inhibit DNA repair. The inhibitory effect can be abrogated by the addition of RU38486, a cortisol antagonist. In addition, we compared plasma cortisol concentration and in vitro DNA repair capacity in 52 healthy individuals. Females on therapeutic estrogen (oral contraceptive or estrogen replacement therapy) had significantly elevated plasma cortisol and suppression of DNA repair capacity.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          03 December 2008
          : 39
          : 5-6
          : 241-246
          Departments of aMicrobiology and bPhysics, Clemson University, Clemson, and cAnderson Family Practice, Anderson, S.C., USA
          182743 Horm Res 1993;39:241–246
          © 1993 S. Karger AG, Basel

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          Pages: 6
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