6
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Evaluation of Biocompatibility of Alloplastic Materials: Development of a Tissue Culture In Vitro Test System.

      Read this article at

      ScienceOpenPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Optimized biocompatibility is a major requirement for alloplastic materials currently applied in surgical approaches for hernia, incontinence, and prolapse situations. Tissue ingrowth/adherence and formation of connective tissue seem to have important influence in mesh incorporation at the implant site. In an in vitro approach we randomly investigated 7 different mesh types currently used in surgeries with various indications with regard to their adherence performance. Using a tissue culture approach, meshes were incubated with tissue representative of fibroblasts, muscle cells, and endothelial cells originating from 10 different patients. After 6 weeks, the meshes were assessed microscopically and a ranking of their adherence performance was established. Tissue culture was successful in 100% of the probes. We did not remark on interindividual differences concerning the growth and adherence performance after incubation with the different meshes in the investigated 10 patients. The ranking was consistent in all patients. In this test system, PVDF Dynamesh® (FEG Textiltechnik, Aachen, Germany) was the mesh with the best growth-in score. The test system was feasible and reproducible. Pore size seems to be a predictor of adherence performance. The test system may be a helpful tool for further investigations, and the predictive value should be assessed in further in vitro and in vivo experiments.

          Related collections

          Author and article information

          Journal
          Surg Technol Int
          Surgical technology international
          1090-3941
          1090-3941
          Dec 2011
          : 21
          Affiliations
          [1 ] Consultant, Department of Urology, Lukas Hospital, Neuss, Germany.
          [2 ] Department of Urology, Lukas Hospital, Neuss, Germany.
          [3 ] Department of General Surgery, Lukas Hospital, Neuss, Germany.
          [4 ] German Centre for Implant-Pathology, Duren, Germany.
          [5 ] Department of Experimental Surgery, University of Szeged, Szeged, Hungary.
          [6 ] Department of Urology, Theodor Bilharz Research Institute, Cairo, Egypt.
          [7 ] Institute for Pathophysiology, University of Essen, Essen, Germany.
          [8 ] Department of Urology, Lukas Hospital, Neuss, Germany, Oncologist, West German Cancer Center, University of Essen, Essen, Germany.
          Article
          sti21/21
          22504966
          3d278413-afb2-4d60-8e39-36514bdd7c20
          History

          Comments

          Comment on this article