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Abstract
The synthesis of β-(1→4)-linked hexa- to octamannoses and their partially acetylated
derivatives was efficiently carried out by assembly of appropriate oligomeric fragments
using β-selective glucosylation followed by gluco to manno epimerization at a late
stage of the synthetic pathway. In the course of this study, we also observed that
2-O-acetylated oligomannoses coexisted in equilibrium with the 3-O-acetylated isomers
due to intramolecular migration of the acetyl group. Bioactivity of the synthetic
oligomannoses and partially acetylated derivatives was investigated in order to identify
the possible smallest oligomer for induction of cytokines as that shown in the polysaccharides
extracted from Dendrobium huoshanense.