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      Pharmacokinetics of the citrus flavanone aglycones hesperetin and naringenin after single oral administration in human subjects.

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          Abstract

          Hesperetin and naringenin, the aglycones of the flavanone glycosides hesperidin and naringin, occur naturally in citrus fruits. They exert interesting pharmacological properties such as antioxidant, anti-inflammatory, blood lipid and cholesterol lowering and are considered to contribute to health benefits in humans. However, no information is available on the pharmacokinetics of the citrus flavanones hesperetin and naringenin after their oral administration to humans as pure aglycones. Therefore, the objective of the present investigation was the evaluation of the pharmacokinetic parameters of hesperetin and naringenin in plasma and urine, after their single oral administration in humans in the form of solid dispersion capsules, and also to improve the absorption rate of flavanones by using aglycones rather than the naturally occurring glycosides.

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          Author and article information

          Journal
          Eur J Clin Nutr
          European journal of clinical nutrition
          Springer Science and Business Media LLC
          0954-3007
          0954-3007
          Apr 2007
          : 61
          : 4
          Affiliations
          [1 ] Department of Pharmacy, Aristotle University of Thessaloniki, Thessaloniki, Greece.
          Article
          1602543
          10.1038/sj.ejcn.1602543
          17047689
          3d62b5d5-2ebc-4a65-b3c2-4137bea55ba5
          History

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