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      Nephritogenicity of Anti-Engelbreth-Holm-Swarm Sarcoma Antibody

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          Abstract

          We have examined the antibody activity and nephritogenicity of anti-Engelbreth-Holm-Swarm (EHS) sarcoma antiserum in order to analyze the pathogenesis of the EHS nephropathy which has already been reported by us. An increased amount of urine protein was not recognized in rats injected with a large quantity of anti-EHS sarcoma antiserum. In addition, rats immunized with rabbit IgG before anti-EHS sarcoma antiserum injection developed no abnormal proteinuria, despite positive fluorescent staining for rat IgG as well as rabbit IgG in the glomeruli. From these results we concluded that nephritogenic antibodies could not be produced in rabbits by immunization with EHS sarcoma, which could induce the EHS nephropathy in an active model.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1987
          1987
          05 December 2008
          : 47
          : 2
          : 150-154
          Affiliations
          aDepartment of Immunology, Institute of Nephrology; bSecond Department of Internal Medicine, and Departments of cDermatology and dPathology, Institute of Nephrology, Niigata University School of Medicine, Niigata, Japan
          Article
          184479 Nephron 1987;47:150–154
          10.1159/000184479
          3320777
          © 1987 S. Karger AG, Basel

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          Page count
          Pages: 5
          Categories
          Original Paper

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