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      Roles of Pin1 as a Key Molecule for EMT Induction by Activation of STAT3 and NF-κB in Human Gallbladder Cancer.

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          Abstract

          Despite developments in multidisciplinary treatment, the prognosis for advanced gallbladder cancer (GBC) still is poor because of its rapid progression. Epithelial-mesenchymal transition (EMT) plays a central role in promoting tumor invasion and metastasis in malignancies thorough signal transducer and activator of transcription-3 (STAT3) and nuclear factor κB (NF-κB) activation. Whereas Pin1 mediates STAT3 and NF-κB activation, the involvement of Pin1 in GBC progression is unclear.

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          Author and article information

          Journal
          Ann. Surg. Oncol.
          Annals of surgical oncology
          Springer Science and Business Media LLC
          1534-4681
          1068-9265
          Mar 2019
          : 26
          : 3
          Affiliations
          [1 ] Department of General Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.
          [2 ] Department of General Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan. satoshi.kuboki@faculty.chiba-u.jp.
          Article
          10.1245/s10434-018-07132-7
          10.1245/s10434-018-07132-7
          30610554
          3d751ed8-3f2c-48c1-b934-06d3a021ca3a
          History

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