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      Alpha- and Beta-Components of the Popliteal Efferent Lymph Flow Response to Intra-Arterial Catecholamine Infusions in the Sheep

      , ,

      Journal of Vascular Research

      S. Karger AG

      Sheep hindlimb, Lymph flow, Norepinephrine, Isoproterenol, Acetylcholine

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          Abstract

          Lymph flow and lymphatic pressure fluctuations were measured in cannulated popliteal efferent lymphatics of the sheep. Five-minute intra-arterial infusions of norepinephrine (0.4 µg/kg/min) produced up to fivefold increases in lymph flow and lymphatic contraction frequency. This effect was blocked by the α-antagonist phentolamine but not by the P-antagonist propranolol. Isoproterenol (0.4 µg/kg/min i.a.) inhibited flow. This effect was antagonized by propranolol. Acetylcholine (0.4 µg/kg/min) had little effect on lymph flow. Since norepinephrine and isoproterenol respectively stimulate and inhibit lymphatic pumping activity in vitro, it is proposed that the effects of these agents on lymph flow and lymphatic contraction frequency in vivo are best explained by direct modulatory actions on the lymphatic smooth muscle pump.

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          Author and article information

          Journal
          JVR
          J Vasc Res
          10.1159/issn.1018-1172
          Journal of Vascular Research
          S. Karger AG
          1018-1172
          1423-0135
          1989
          1989
          23 September 2008
          : 26
          : 2
          : 107-118
          Affiliations
          Department of Physiology, The Queen’s University of Belfast, Northern Ireland, UK
          Article
          158759 Blood Vessels 1989;26:107–118
          10.1159/000158759
          © 1989 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 12
          Categories
          Research Paper

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