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      Alpha- and Beta-Components of the Popliteal Efferent Lymph Flow Response to Intra-Arterial Catecholamine Infusions in the Sheep

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      Journal of Vascular Research

      S. Karger AG

      Sheep hindlimb, Lymph flow, Norepinephrine, Isoproterenol, Acetylcholine

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          Lymph flow and lymphatic pressure fluctuations were measured in cannulated popliteal efferent lymphatics of the sheep. Five-minute intra-arterial infusions of norepinephrine (0.4 µg/kg/min) produced up to fivefold increases in lymph flow and lymphatic contraction frequency. This effect was blocked by the α-antagonist phentolamine but not by the P-antagonist propranolol. Isoproterenol (0.4 µg/kg/min i.a.) inhibited flow. This effect was antagonized by propranolol. Acetylcholine (0.4 µg/kg/min) had little effect on lymph flow. Since norepinephrine and isoproterenol respectively stimulate and inhibit lymphatic pumping activity in vitro, it is proposed that the effects of these agents on lymph flow and lymphatic contraction frequency in vivo are best explained by direct modulatory actions on the lymphatic smooth muscle pump.

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          Author and article information

          J Vasc Res
          Journal of Vascular Research
          S. Karger AG
          23 September 2008
          : 26
          : 2
          : 107-118
          Department of Physiology, The Queen’s University of Belfast, Northern Ireland, UK
          158759 Blood Vessels 1989;26:107–118
          © 1989 S. Karger AG, Basel

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          Page count
          Pages: 12
          Research Paper


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