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      Changes in the Visual System of Rabbit Fetuses after Thalidomide Administration

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          Abstract

          76 eyes with appendages were obtained from rabbit fetuses whose mothers received thalidomide orally in doses of 150 and 300 mg/kg from the 7th to 16th days of pregnancy. In most fetuses, multiple deformities were observed in the extremities resembling those described after thalidomide administration by other authors. In only two fetuses, microphthalmia was observed after doses of the drug with incomplete separation, of iris, absence of sphincter and dilatator muscles, choroid coloboma and retinal dysplasia. Histological examinations disclosed changes of the external muscles of the eye with signs of congenital myopathy in 24 fetuses. In corneas of 12 fetuses, the presence of undifferentiated keratocytes was observed lying among plicated collagenous fibers.

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          Author and article information

          Journal
          ORE
          Ophthalmic Res
          10.1159/issn.0030-3747
          Ophthalmic Research
          S. Karger AG
          0030-3747
          1423-0259
          1976
          1976
          03 December 2009
          : 8
          : 2
          : 146-151
          Affiliations
          Department of Pathological Anatomy (Head: Prof. S. Kruś), Institute of Biostructure, Medical Academy, and Department of Pharmacology (Head: Prof. A. Danysz), Institute of Drugs Research, Warsaw
          Article
          264809 Ophthalmic Res 1976;8:146–151
          10.1159/000264809
          © 1976 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

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          Pages: 6
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