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      Changes in the Visual System of Rabbit Fetuses after Thalidomide Administration

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          76 eyes with appendages were obtained from rabbit fetuses whose mothers received thalidomide orally in doses of 150 and 300 mg/kg from the 7th to 16th days of pregnancy. In most fetuses, multiple deformities were observed in the extremities resembling those described after thalidomide administration by other authors. In only two fetuses, microphthalmia was observed after doses of the drug with incomplete separation, of iris, absence of sphincter and dilatator muscles, choroid coloboma and retinal dysplasia. Histological examinations disclosed changes of the external muscles of the eye with signs of congenital myopathy in 24 fetuses. In corneas of 12 fetuses, the presence of undifferentiated keratocytes was observed lying among plicated collagenous fibers.

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          Ophthalmic Res
          Ophthalmic Research
          S. Karger AG
          03 December 2009
          : 8
          : 2
          : 146-151
          Department of Pathological Anatomy (Head: Prof. S. Kruś), Institute of Biostructure, Medical Academy, and Department of Pharmacology (Head: Prof. A. Danysz), Institute of Drugs Research, Warsaw
          264809 Ophthalmic Res 1976;8:146–151
          © 1976 S. Karger AG, Basel

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          Pages: 6


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