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      Exhaustive database searching for amino acid mutations in proteomes.

      1 ,
      Bioinformatics (Oxford, England)

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          Abstract

          Amino acid mutations in proteins can be found by searching tandem mass spectra acquired in shotgun proteomics experiments against protein sequences predicted from genomes. Traditionally, unconstrained searches for amino acid mutations have been accomplished by using a sequence tagging approach that combines de novo sequencing with database searching. However, this approach is limited by the performance of de novo sequencing.

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          Author and article information

          Journal
          Bioinformatics
          Bioinformatics (Oxford, England)
          1367-4811
          1367-4803
          Jul 15 2012
          : 28
          : 14
          Affiliations
          [1 ] BioSciences Division, Oak Ridge National Laboratory, Oak Ridge, TN, USA.
          Article
          bts274
          10.1093/bioinformatics/bts274
          22581177
          3d8c64f4-5d53-464f-9df3-c8fe6e5b266c
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