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Abstract
Congenital anatomic variants of the pancreatic duct are rare. Variant anatomy may
be discovered incidentally or it may cause a wide range of symptoms. EUS is a minimally
invasive diagnostic test for anatomic variants in the pancreatic duct. The aim of
this video is to elucidate EUS images demonstrating 3 different variants of the pancreatic
ductal anatomy with radiologic corroboration and motion animation (Video 1, available
online at www.VideoGIE.org).
The first patient was a 48-year-old woman with a history of chronic abdominal pain
and idiopathic recurrent acute pancreatitis. She had persistent symptoms after cholecystectomy
and was receiving long-term narcotic agents. Evaluation by MRI and laboratory studies
at an outside hospital were unrevealing. EUS evaluation showed a dominant dorsal pancreatic
duct (PD) draining into the minor papilla, compatible with pancreas divisum (Fig. 1A).
Repeated MRI with secretin confirmed the diagnosis of pancreas divisum (Fig. 1B).
The patient underwent ERCP with minor papilla sphincterotomy and balloon sphincteroplasty.
She had complete relief of pain without recurrent pancreatitis during a 1-year follow-up.
Figure 1
A, Left, probe of a linear echoendosocope facing the minor papilla in a representative
case of pancreas divisum. Right, corresponding EUS image showing drainage of the dominant
pancreatic duct (PD) into the minor papilla. B, MRI image showing drainage of a dominant
pancreatic duct into the minor papilla (red arrow), compatible with pancreas divisum
diagnosis. C, Left, probe of a linear echoendosocope facing the ampulla in a representative
case of pancreaticobiliary maljunction. Right, corresponding EUS image showing the
pancreaticobiliary maljunction resulting in a long common channel. D, MRI demonstrating
the pancreaticobiliary maljunction and a 15-mm-long common channel. E, Follow-up MRI
from a patient with side-branch intraductal papillary mucinous neoplasia in the head
of the pancreas, revealing a bifid pancreatic duct (red arrow). F, Curvilinear echoendoscopic
view from the stomach showing a bifurcated pancreatic duct arising from the body of
the pancreas. CBD, common bile duct.
The second patient was a 52-year-old woman with chronic, vague upper-abdominal pain.
Her review of systems was otherwise unremarkable. Investigations revealed normal results
of liver blood tests, EGD, and CT scan. EUS showed an anomalous junction between the
pancreatic duct and the bile duct outside the duodenal wall, resulting in a long common
channel (Fig. 1C). MRI confirmed the EUS findings (Fig. 1D). Because of the higher
risk of gallbladder cancer associated with pancreatobiliary maljunction, prophylactic
cholecystectomy was recommended.
The third patient was a 75-year-old woman with a history of asymptomatic side-branch
intraductal papillary mucinous neoplasia (IPMN). Follow-up imaging with MRI revealed
a bifid pancreatic duct arising from the body of the pancreas (Fig. 1E). This finding
was also well observed and illustrated by EUS evaluation (Fig. 1F). No relevant clinical
significance related with bifid PD has been reported in the literature, and the patient
continues to receive imaging surveillance of the side-branch IPMN.
Although noninvasive imaging such as US, CT, and MRI are accurate diagnostic tests
for anatomic variants in the pancreas, as illustrated in these cases, some patients
may receive misdiagnoses. EUS is a safe and reliable test for diagnosing variant pancreatic
ductal anatomy in patients with high clinical suspicion and nondiagnostic noninvasive
imaging test results.
Disclosure
All authors disclosed no financial relationships relevant to this publication.