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      Intraluminal Flow Preferentially Increases Net Sodium Uptake in the Rabbit Facial Vein

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          Abstract

          The infusion of physiological salt solution into the lumen of ring segments of the isolated rabbit facial vein induces an increase in vessel wall tone. Changes in <sup>22</sup>Na<sup>+</sup> and <sup>45</sup>Ca<sup>2+</sup> net uptake as well as <sup>22</sup>Na<sup>+</sup> unidirectional efflux in response to flow in this vessel were compared to the response to histamine (1 µ M) and to angiotensin II (0.1 µ M). <sup>22</sup>Na<sup>+</sup> net uptake per unit force developed in response to flow was 7.9-fold greater than that for histamine (1 µ M) and twice that for angiotensin II (0.1 µ M). In comparison, <sup>45</sup>Ca<sup>2+</sup> net uptake per unit force in response to flow, histamine and K<sup>+</sup> were similar. Flow-induced contraction and the related <sup>45</sup>Ca<sup>2+</sup> and <sup>22</sup>Na<sup>+</sup> net uptake were decreased by amiloride (30 µ M) and methyl isobutyl amiloride (30 µ M) without changes in <sup>45</sup>Ca<sup>2+</sup> or <sup>22</sup>Na<sup>+</sup> net uptake per unit force. Ouabain (10 µ M) enhanced flow-induced contraction and the related <sup>22</sup>Na<sup>+</sup> net uptake. Both ouabain (10 µ M) and Bay K 8644 (1 µ M) increased flow-induced contraction and the related <sup>45</sup>Ca<sup>2+</sup> net uptake whereas they decreased the <sup>45</sup>Ca<sup>2+</sup> net uptake per unit force. Flow, histamine and angiotensin II increased the unidirectional efflux of <sup>22</sup>Na<sup>+</sup>. This increase in <sup>22</sup>Na<sup>+</sup> unidirectional efflux was attenuated by ouabain (10 µ M). These experiments demonstrate that the increases in wall force due to flow, histamine and angiotensin II are associated with increases in <sup>22</sup>Na<sup>+</sup> net uptake and unidirectional efflux. Flow preferentially promotes the entry of Na<sup>+</sup>, compared to histamine and angiotensin II.

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          Author and article information

          Journal
          JVR
          J Vasc Res
          10.1159/issn.1018-1172
          Journal of Vascular Research
          S. Karger AG
          1018-1172
          1423-0135
          1995
          1995
          24 September 2008
          : 32
          : 6
          : 413-422
          Affiliations
          aInstitut National de la Santé et de la Recherche Médicale Unit 141, IFR Circulation Lariboisière, Hôpital Lariboisière, Paris, France; bDepartment of Pharmacology and Vermont Center for Vascular Research, College of Medicine, University of Vermont, Burlington, Vt., USA
          Article
          159117 J Vasc Res 1995;32:413–422
          10.1159/000159117
          8562814
          © 1995 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 10
          Categories
          Research Paper

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