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      Regulation of intestinal epithelial permeability by tight junctions.

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      Cellular and molecular life sciences : CMLS
      Springer Science and Business Media LLC

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          Abstract

          The gastrointestinal epithelium forms the boundary between the body and external environment. It effectively provides a selective permeable barrier that limits the permeation of luminal noxious molecules, such as pathogens, toxins, and antigens, while allowing the appropriate absorption of nutrients and water. This selective permeable barrier is achieved by intercellular tight junction (TJ) structures, which regulate paracellular permeability. Disruption of the intestinal TJ barrier, followed by permeation of luminal noxious molecules, induces a perturbation of the mucosal immune system and inflammation, and can act as a trigger for the development of intestinal and systemic diseases. In this context, much effort has been taken to understand the roles of extracellular factors, including cytokines, pathogens, and food factors, for the regulation of the intestinal TJ barrier. Here, I discuss the regulation of the intestinal TJ barrier together with its implications for the pathogenesis of diseases.

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          Author and article information

          Journal
          Cell Mol Life Sci
          Cellular and molecular life sciences : CMLS
          Springer Science and Business Media LLC
          1420-9071
          1420-682X
          Feb 2013
          : 70
          : 4
          Affiliations
          [1 ] Department of Biofunctional Science and Technology, Graduate School of Biosphere Science, Hiroshima University, 1-4-4, Kagamiyama, Higashi-Hiroshima, 739-8528, Japan. takuya@hiroshima-u.ac.jp
          Article
          10.1007/s00018-012-1070-x
          22782113
          3da636c7-d97a-4a19-ba53-9e9c0682989d
          History

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