Tuberculosis (TB) is still a deadly disease in 2019. It ranks among the top 10 causes
of death globally and is the most frequent cause of death from a single infectious
agent. TB remains a major public health problem worldwide, with the highest disease
burden in low- and middle-income countries; according to the World Health Organization
(WHO), an estimated 10 million people fell ill with tuberculosis in 2017, 1.5 million
of whom died [1]. Children under 5 years of age are especially at risk of developing
severe disease manifestations such as meningeal or disseminated disease and are therefore
at higher risk of death and sequelae. In addition, young children with untreated latent
TB infection (LTBI) or disease may experience reactivated TB later in life, which
poses a major obstacle for elimination of the disease.
A total of 3% of global TB cases occur in the WHO European Region [1]. From a global
perspective, the European Union/European Economic Area (EU/EEA)—which comprises 31
of the 53 countries in the Region—is making much progress, with decreasing numbers
of people getting sick from TB or dying from the disease [2]. Despite this improvement,
several problems remain that need to be considered. In the EU/EEA, the frequency and
burden of TB varies considerably between countries, with country-specific notification
rates ranging from 2.6 in Liechtenstein to 66.2 per 100,000 in Romania [2]. Within
the EU/EEA, TB is largely a disease of the poor, affecting the most vulnerable and
impoverished population groups. In Portugal, for example, unemployed individuals were
shown to be at higher risk of developing TB [3]. In France, the TB notification rate
is 10 times higher in foreign-born individuals compared with the native population,
and in homeless individuals this rate was 166 per 100,000 in 2015 [4]. Though the
EU/EEA has a relatively low incidence of TB compared to the rest of the world, thousands
of people still die from the disease every year, even though it can usually be cured
by timely treatment with an adequate and complete drug regimen. The high number of
multidrug-resistant (MDR) TB cases in some countries remains a constant threat for
local populations and, because of travel and migration, also puts at risk those living
in bordering countries and other parts of Europe. At 3.8%, the proportion of MDR TB
in Germany in 2017 was almost four times higher in foreign-born individuals compared
to those born in Germany (1.0%); for those born in the newly independent states of
the former Soviet Union, this proportion was almost 20 times higher (19.3%) [5].
The present issue of Eurosurveillance features two articles that discuss issues that
the EU/EEA is facing regarding TB control. The incidence of TB in most EU/EEA countries
is decreasing and this is encouraging. However, one important question is whether
the current rate of decrease is enough to meet the targets that all WHO Member States
committed to in 2015 to reduce cases of TB and deaths from the disease [6]. This point
is discussed by Merk et al., who describe the trends of TB incidence and deaths reported
in the EU/EEA during the last decade [7]. The authors show that despite a clear annual
decline in cases and deaths, the trend is not enough to reach the set objectives.
They also point out that some countries are progressing towards ending TB faster than
others, and underline the need to adapt prevention and control measures to a particular
country’s situation. Despite substantial improvements in TB control in the EU/EEA,
and the fact that the disease is progressively becoming rare in many countries, Merk
et al. highlight that further progress in controlling and finally eliminating this
severe disease will require a constant effort that is continually adapted to suit
distinct geographical areas and the most affected population groups.
Treatment outcome of TB patients and factors that may influence treatment success
are further key points in TB control, and these are discussed in an article by Karo
et al. in this issue of Eurosurveillance [8]. Adequate treatment of a TB case cures
the patient, rapidly limits the risk of transmission of Mycobacterium tuberculosis
to close contacts in the family and community, and prevents the development of resistance
to anti-TB drugs. Therefore, assessing patients’ treatment outcome remains essential
for evaluating national TB control programs; further, identifying factors associated
with an unfavourable outcome may help to target control measures in groups that are
most at need. In their analysis of factors influencing treatment outcome of TB in
Europe, Karo et al. showed an almost nine times higher risk of unsuccessful treatment
for patients with MDR TB (Odds ratio (OR): 8.7; 95% confidence interval (CI): 5.09–14.97)
[9]. The retrospective analysis in this issue used information on treatment outcome
compiled by the European Centre for Disease Prevention and Control (ECDC) in the European
Surveillance System (TESSy) database to investigate the association between isoniazid
(INH) mono-resistance and TB treatment success. The results show that treatment success
did not meet the objectives set by WHO in 2014 [6] and that treatment success for
INH mono-resistant TB was significantly lower compared with fully drug-susceptible
TB. The authors compare their results to those already published and conclude that
increased efforts should be made towards timely detection and management of INH mono-resistant
TB, which is frequently underestimated. Timely drug sensitivity testing of all cases
and provision of treatment regimens adapted to the strain profile are essential components
of TB control that contribute to maintaining a low prevalence of INH mono-resistance
observed in the EU/EEA [10]. The timely identification and management of patients
infected with a strain resistant to INH, one of the most important first-line drugs
for the treatment of TB, should also prevent further development of MDR TB, which
remains low overall in most countries of the EU/EEA [2].
It is clear that ending the TB epidemic poses tremendous challenges and requires a
concerted international effort. Following the 1993 WHO alert declaring that TB was
a global emergency [11], several initiatives (e.g. Stop TB Partnership), sources of
funding (e.g. The Global Fund) and political declarations have shown that the international
community is committed to the global goal of ending the TB epidemic. In November 2017,
the first WHO global ministerial conference on ending TB was held in the Russian Federation
and brought together 75 ministers of health, resulting in the Moscow Declaration to
End TB [12]. The conference recognised that today TB is the most deadly infectious
disease in the world, with considerable economic and social consequences. On 26 September
2018, the United Nations first high-level meeting on TB in New York highlighted the
need for immediate action to accelerate progress towards the goal of ending the TB
epidemic by 2030. In the political declaration, national leaders committed to taking
specific actions against TB [13].
The elimination of TB in the EU/EEA, where a growing number of countries are progressively
entering the low-incidence category, poses several challenges, as illustrated by the
two articles presented in this issue of Eurosurveillance. The elimination of TB in
this region will require additional efforts and specific actions that have been adapted
to local epidemiology [14]. Treatment outcome needs to improve, particularly in drug-resistant
TB cases, including cases with MDR TB, which is associated with the highest rates
of unsuccessful treatment [9]; in order to achieve this, a wider use of rapid molecular
testing and the adaptation of treatment regimens are necessary. Continual involvement
of TB professionals and close collaboration between clinicians, microbiologists and
epidemiologists working in the field are also needed. Immediate contact investigations
performed around each newly detected case will help to prevent the occurrence of new
cases. The use of genotyping methods to identify related cases and to understand chains
of transmission should further help to get closer to a zero transmission goal.
In low-incidence countries, the majority of TB cases are generated through reactivation
of latent TB infections (LTBI) acquired abroad [14]. As global migration has increased
considerably in recent decades [15,16] and a significant proportion of TB cases in
most EU/EEA countries are born in countries with a high incidence of TB [2], early
detection and access to health services and care in this specific group should be
placed as one of the top priorities of TB control. In addition, individuals with LTBI
represent an important reservoir, as they may later progress to TB disease, therefore
contributing to future TB burden. In the WHO European Region the prevalence of LTBI
has been estimated at 13.7%; this prevalence is 0.3% for recent infections [17], which
have the highest risk of progressing towards TB. An important challenge for European
control programs is therefore to establish a programmatic approach to LTBI management
that takes into account the TB epidemiology in various vulnerable groups, as well
as the health system structure, resource allocation and political commitment [18].
This underlines that there is not one single issue to address, but rather that a strategic,
comprehensive approach needs to be developed in order to meet the challenge of TB
elimination.