Sites and Mechanisms of the Excretion of Allantoin by the Rat Kidney

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Abstract

<sup>14</sup>C-allantoin is freely filtered into glomerular fluid and both secreted into and reabsorbed from tubule fluid, as disclosed by clearance, micropuncture, microinjection, surface drop deposition, tissue analysis, and in vitro slice methods. Secretion, resulting in proximal fractional deliveries of 1.12 ± 0.05 (n = 53), was inhibited by PAH, probenecid and salicylate, but neither by creatinine nor by N<sub>1</sub>-methylnicotinamide. Reabsorption along the whole nephron resulted in a fractional excretion between 0.8 and 0.9 in the nondiuretic state which increased above unity at high rates of urine flow.

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Author and article information

Journal

Journal ID (publisher-id): KBR

Journal ID (nlm-ta): Kidney Blood Press Res

Journal ID (doi): 10.1159/issn.1420-4096

Title: Kidney and Blood Pressure Research

Publisher: S. Karger AG

ISSN (Print): 1420-4096

ISSN (Electronic): 1423-0143

Publication date Subscription-year: 1978

Publication date (Print): 1978

Publication date (Electronic): 06 November 2008

Volume: 1

Issue: 4

Pages: 223-234

Affiliations

Institut de pharmacologie de I’Université de Lausanne, Lausanne, Switzerland, and Laboratoire rénal, Département de médecine, Université de Louvain, Louvain, Belgium

Article

Publisher ID: 172665 Other ID: Renal Physiol 1978;1:223–234

DOI: 10.1159/000172665

SO-VID: 3dbf1dfd-b267-47ae-8287-bef101d94cc5

License:

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date accepted : 17 January 1979

Page count

Pages: 12

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