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      Natural Product Synthesis via Palladium-Catalyzed Carbonylation.

      1 , 1 , 1
      The Journal of organic chemistry
      American Chemical Society (ACS)

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          Abstract

          Carbon monoxide is an important one-carbon source and can be incorporated in complex molecules via various transition-metal-catalyzed carbonylation reactions. In particular, palladium-catalyzed carbonylation reactions have found broad application in total synthesis of natural products. Examples are presented in this Synopsis to highlight recent progress in this area, including our own work in macrolide and spirocyclic molecule synthesis. In these selected cases, carbon monoxide functions as a one-carbon linchpin to facilitate building structural complexity and improving synthetic efficiency.

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          Author and article information

          Journal
          J Org Chem
          The Journal of organic chemistry
          American Chemical Society (ACS)
          1520-6904
          0022-3263
          March 03 2017
          : 82
          : 5
          Affiliations
          [1 ] Department of Chemistry and Center for Cancer Research, Purdue University , West Lafayette, Indiana 47907, United States.
          Article
          10.1021/acs.joc.7b00009
          28170262
          3dcbb703-7b46-480d-b607-368367d19808
          History

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