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      New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions.

      Nature reviews. Immunology

      Animals, Cytokines, immunology, Humans, Inflammation, Interleukin-12, classification, genetics, Interleukin-23, Interleukin-23 Subunit p19, Interleukins, physiology, Mice, Mice, Knockout, Th1 Cells

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          Abstract

          Understanding the factors that influence T helper 1 (T(H)1)- and T(H)2-cell responses has been one of the main focuses of immunology for almost 20 years. Whereas the central role of interleukin-12 (IL-12) in the generation of T(H)1 cells has long been appreciated, subsequent studies indicated that IL-23 and IL-27, two cytokines that are closely related to IL-12, also regulate T(H)1-cell responses. However, as discussed in this article, it is now recognized that the ability of IL-23 to stimulate a unique T-cell subset to produce IL-17 has a dominant role in autoimmune inflammation. By contrast, IL-27 has a role in limiting the intensity and duration of adaptive immune responses.

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          Journal
          15999093
          10.1038/nri1648

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