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      WTAP Expression Predicts Poor Prognosis in Malignant Glioma Patients.

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          Abstract

          Wilms' tumor 1-associating protein (WTAP) interacts with the Wilms' tumor 1 gene. Although originally classified as a tumor suppressor, WTAP was later found to be over-expressed in glioblastoma which is regarded as a grade IV astrocytoma. However, the expression in other glioma grades and the relationship between WTAP expression and the prognosis of glioma patients are still unknown. In this study, we investigated WTAP expression in 169 different types of glioma cases using western blot analysis and immunohistochemistry assay. Further, we evaluated the association of WTAP expression with clinicopathological characteristics using chi-square test and Spearman's correlation test. We used univariate and multivariate Cox regression analyses to evaluate the independency of diferent WTAP expression. Then, the survival curves were calculated using the Kaplan-Meier method. Results showed that WTAP was over-expressed in glioma tissues, and the expression was closely correlated with glioma grade. Moreover, high WTAP expression was correlated with poor postoperative survival in glioma patients. WTAP may serve as a novel prognostic marker.

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          Author and article information

          Journal
          J. Mol. Neurosci.
          Journal of molecular neuroscience : MN
          Springer Nature America, Inc
          1559-1166
          0895-8696
          Oct 2016
          : 60
          : 2
          Affiliations
          [1 ] Department of Neurosurgery, Shengjing Hospital of China Medical University, Shenyang, 110004, China.
          [2 ] Liaoning Research Center for Translational Medicine in Nervous System Disease, Shenyang, 110004, China.
          [3 ] Department of Neurobiology, College of Basic Medicine, China Medical University, Shenyang, 110122, China.
          [4 ] Institute of Pathology and Pathophysiology, China Medical University, Shenyang, 110122, China.
          [5 ] Department of Neurosurgery, Shengjing Hospital of China Medical University, Shenyang, 110004, China. neurosurgery_sj@163.com.
          [6 ] Liaoning Research Center for Translational Medicine in Nervous System Disease, Shenyang, 110004, China. neurosurgery_sj@163.com.
          Article
          10.1007/s12031-016-0788-6
          10.1007/s12031-016-0788-6
          27370540

          Gliomas, WTAP, Survival analysis, Immunohistochemistry

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