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      Enzymatic glycosylation of small molecules: challenging substrates require tailored catalysts.

      Chemistry (Weinheim an Der Bergstrasse, Germany)

      chemistry, Anti-Bacterial Agents, Vitamins, Substrate Specificity, Protein Engineering, Phosphorylases, Models, Molecular, High-Throughput Screening Assays, Glycosyltransferases, Glycosylation, chemical synthesis, biosynthesis, Glycosides, Glycoside Hydrolases, Flavoring Agents, Carbohydrate Conformation, Biocatalysis

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          Abstract

          Glycosylation can significantly improve the physicochemical and biological properties of small molecules like vitamins, antibiotics, flavors, and fragrances. The chemical synthesis of glycosides is, however, far from trivial and involves multistep routes that generate lots of waste. In this review, biocatalytic alternatives are presented that offer both stricter specificities and higher yields. The advantages and disadvantages of different enzyme classes are discussed and illustrated with a number of recent examples. Progress in the field of enzyme engineering and screening are expected to result in new applications of biocatalytic glycosylation reactions in various industrial sectors. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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          Journal
          10.1002/chem.201103069
          22887462

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