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      Perfusion of the Intact and Partially Isolated Rat Mesenteric Vascular Bed: Application to Vessels from Hypertensive and Normotensive Rats

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          Abstract

          In the present study, we utilized 2 perfused mesenteric vascular bed preparations in an examination of the responses of mesenteric vessels from spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats. One preparation involved perfusion of the mesenteric vascular bed dissected free from the intestine. The second preparation was essentially similar, with the exception that the intestine and the small arterioles feeding the jejunum were intact. The results suggested that the small vessels offer a significant contribution to the mechanical resistance to perfusion in the mesenteric vasculature and are important in the neurogenic responses of this preparation. In contrast, the arterioles in the arcade supplying the jejunum play only a minor role in the responses of the mesenteric vascular bed to intraluminally injected vasoactive substances. It was found that mesenteric preparations from SHR rats responded more forcefully to intraluminally administered norepinephrine and potassium, regardless of whether the intestine was absent or present. Similarly, the responses of mesenteric preparations to electrical nerve stimulation were greater in preparations from SHR rats, particularly when the intestine was present. It is concluded that the perfused mesenteric vasculature from SHR rats is more responsive to vasoactive substances and nerve stimulation and that this feature is not exclusively dependent upon a contribution to contraction by the arterioles supplying the jejunum.

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          Author and article information

          Journal
          JVR
          J Vasc Res
          10.1159/issn.1018-1172
          Journal of Vascular Research
          S. Karger AG
          1018-1172
          1423-0135
          1986
          1986
          23 September 2008
          : 23
          : 6
          : 288-296
          Affiliations
          Department of Pharmacology and Toxicology, West Virginia University Medical Center, Morgantown, W. Va., USA
          Article
          158656 Blood Vessels 1986;23:288–296
          10.1159/000158656
          3df3f3e8-2882-4ec2-aebf-e5ae81b43140
          © 1986 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          : 30 September 1985
          : 22 May 1986
          Page count
          Pages: 9
          Categories
          Research Paper

          General medicine,Neurology,Cardiovascular Medicine,Internal medicine,Nephrology
          Hypertension, spontaneous,Potassium,Norepinephrine,Mesenteric vascular bed,Normotension

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