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      Association of autoimmune blistering disease, and specifically, pemphigus vulgaris, with cardiovascular disease and its risk factors: a systematic review and meta-analysis.

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          Abstract

          Previous studies have found conflicting results about the association of autoimmune blistering disease (AIBD) with cardiovascular disease (CVD) risk. The objective of the study was to systematically review the relationship of AIBD, including pemphigus vulgaris (PV), and its treatment with CVD and CVD risk factors. MEDLINE, EMBASE, Cochrane, LILACS, SCOPUS, and Web of Science were searched. We included all studies of CVD and CVD risk factors in AIBD patients. Two reviewers performed title and/or abstract review and data extraction. Pooled random-effects meta-analysis was performed. Forty papers met inclusion criteria. AIBD was associated with higher odds of diabetes (DM) (odds ratio [95% confidence interval]: 1.809 [1.258-2.601]), hypertension (HTN) (1.393 [1.088-1.784]), dyslipidemia (2.177 [1.163-4.073]) and heart failure (1.919 [1.603-2.298]), but was not associated with obesity, stroke, angina, heart attack, or arrhythmia. The pooled random-effects prevalence for treatment-related adverse events (AEs) in AIBD was 13.7% for DM, 10.7% for HTN, and 17.1% for CVD. Sensitivity analysis of high-quality studies revealed similar results. AIBD patients have increased CVD risk factors and heart failure. Systemic corticosteroid treatment results in CVD-related AEs in AIBD. Increased CVD screening and prevention strategies are warranted in AIBD.

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          Author and article information

          Journal
          Arch Dermatol Res
          Archives of dermatological research
          Springer Science and Business Media LLC
          1432-069X
          0340-3696
          Mar 2023
          : 315
          : 2
          Affiliations
          [1 ] The University of Illinois at Chicago, Chicago, IL, USA.
          [2 ] NYU Langone Hospital - Long Island, Mineola, NY, USA.
          [3 ] AMITA Health Saint Joseph Hospital Chicago, Chicago, IL, USA.
          [4 ] Departments of Medicine and Dermatology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
          [5 ] Department of Dermatology, State University of New York Downstate Medical Center, Brooklyn, NY, USA.
          [6 ] Department of Dermatology, the George Washington University School of Medicine and Health Sciences, 2150 Pennsylvania Avenue NW Suite 2B-425, Washington, DC, 20037, USA. JonathanISilverberg@Gmail.com.
          Article
          10.1007/s00403-022-02346-y
          10.1007/s00403-022-02346-y
          35262797
          3dfe868f-cf1d-4e3d-96e5-cc890e5829c3
          History

          Hypertension,Pemphigus vulgaris,Cardiovascular disease,Comorbidity,Dyslipidemia,Diabetes

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