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      Association of chondromodulin-II Val58Ile polymorphism with radiographic joint destruction in rheumatoid arthritis.

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          Abstract

          Chondromodulin-II (ChM-II) is a cartilage-derived protein involved in cartilage and bone repair. A study of Japanese patients with rheumatoid arthritis (RA) implicated an association between a 172G --> A (Val58Ile) polymorphism and radiographic damage. We analyzed ChM-II for polymorphisms and investigated the association with radiographically assessed joint destruction in German patients with RA. Possible interactions with the shared epitope (SE) were examined.

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          Author and article information

          Journal
          J Rheumatol
          The Journal of rheumatology
          0315-162X
          0315-162X
          Sep 2005
          : 32
          : 9
          Affiliations
          [1 ] Department of Pathological Biochemistry, Institute of Medical Informatics and Biometry, Carl Gustav Carus Medical School, University of Technology Dresden, Germany. Juergen.Graessler@mailbox.tu-dresden.de
          Article
          0315162X-32-1654
          16142856
          3e1771a8-1740-4666-bed8-7cd4f0ec7411
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