Model for laser Doppler measurements of blood flow in tissue

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

A theory is developed which relates quasi-elastic light scattering measurements to blood flow in tissue micro-vasculature. We assume that the tissue matrix surrounding the blood cells is a strong diffuser of light and that moving erythrocytes, therefore, are illuminated by a spatially distributed source. Because the surrounding tissue is considered to be stationary, Doppler shifts in the frequency of the scattered light arise only from photon interactions with the moving blood cells. The theory implies that the time decay of the photon autocorrelation function scales proportionally with cell size and inversely with mean translational speed. Analysis of multiple interactions of photons with moving cells indicates the manner in which spectral measurements additionally are sensitive to changes in blood volume. Predictions are verified by measurements of particle flow in model tissues.

Related collections

Most cited references 14

Record: found
Abstract: not found
Article: not found

In vivo evaluation of microcirculation by coherent light scattering.

Andrew M Stern (1975)

0 comments Cited 80 times – based on 0 reviews      Review now

Record: found
Abstract: found
Article: not found

Diffuse reflectance from a finite blood medium: applications to the modeling of fiber optic catheters.

Larry Reynolds, C. Johnson, A. Ishimaru (1976)

The scattering and absorption of light by randomly oriented, discretely scattering, red blood cells imbedded in a homogeneous plasma medium can be described by the P1 approximation to the one-speed transport equation, where the cells have the dual role of anisotropic sources for first scattering events and of scattering and absorption sites for subsequent scattering events. Equations for diffuse reflectance defined for a finite size receiver in the plane of a normally incident cylindrical photon beam are derived and compared with experimental data to fundamentally justify the basic sending-receiving characteristics of a fiber optic catheter model. A model of the fiber optic catheter used for the spectrophotometric measurement of oxygen content in blood is developed from the theory and compared with experimental results to further substantiate the theoretical approach.