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      Isoelectric Focusing of γ-Crystallins

      , ,

      Ophthalmic Research

      S. Karger AG

      Isoelectric focusing, γ-crystallins, Eye lens, Cross-linking, SH- and -SS-groups, Aging, Rat

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          Changes in the distribution of γ-crystallins in the lenses of rats between 1 and 52 weeks of age were studied by isoelectric focusing. Generally levels of components with high isoelectric pointwere depressed while those with low isoelectric point were elevated during this time. The in vitro incorporation of <sup>14</sup>C amino acids by those components decreasing in level was diminished with increasing age, while an enhancement of incorporation was found for components increasing in level. Evidence that the components present at high levels in the nucleus (i.e.: the oldest part of the lens) are converted to urea-insoluble material is given.

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          Author and article information

          Ophthalmic Res
          Ophthalmic Research
          S. Karger AG
          27 November 2009
          : 2
          : 2
          : 110-115
          Department of Surgery (Ophthalmology and Biochemistry), University of Rochester School of Medicine, Rochester, N.Y.
          264550 Ophthal Res 1971;2:110–115
          © 1971 S. Karger AG, Basel

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          Pages: 6


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