Shigeto Ishidoya a , Atsushi Fukuzaki a , Hiroyuki Kaneto a , Atsushi Takeda a , Yukihiko Ogata a , Toru Sasaki a , Ken-ichi Suzuki a , Ryuji Watanabe a , Senji Hoshi a , Masahiro Kikuya b , Kazuhisa Takeuchi b , Sadayoshi Ito b , Seiichi Orikasa a
31 May 2000
A 50-year-old woman developed renin-dependent hypertension immediately after accidental unilateral ureteral ligation during hysterectomy, and the hypertension lasted for 5 months. Surgical release of the obstruction was carried out 157 days after the ligation. Then, her blood pressure was normalized. However, the obstructed kidney showed intensive tubulointerstitial fibrosis and functional recovery was not obtained. This case suggests that the renin-angiotensin system may be upregulated in human kidney during unilateral ureteral obstruction for a long duration.