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      Hormonal Regulation of Postnatal Growth in Children Born Small for Gestational Age

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          Children born small for gestational age (SGA) are at high risk of permanent short stature, with approximately 10% continuing to have stature below the third centile throughout childhood and adolescence and into adulthood. The mechanisms involved in catch-up growth, and those that prevent catch-up growth, are still unknown. To date, no reliable anthropometric or endocrine parameter predictive of postnatal catch-up growth has been identified. However, subtle abnormalities in the growth hormone-insulin-like growth factor axis, the hypothalamic-pituitary-adrenal axis and thyroid function have been described, and a mechanism involving intrauterine programming of hypothalamic-pituitary function has been proposed.

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          Most cited references 17

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          Intrauterine growth retardation and postnatal growth failure associated with deletion of the insulin-like growth factor I gene.

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            Insulin-like growth factors and their binding proteins: biological actions

             J Jones (1995)
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              Maternal and environmental influences on the adrenocortical response to stress in weanling rats.

              Handling rat pups either for 10 or 20 days after birth resulted in a reduction of adrenocortical steroids in the plasma at weaning after the pups were exposed to novel stimuli as compared with controls that were not handled. Nonhandled offspring of mothers which had been handled in infancy also show a reduction in plasma steroids in response to novel stimuli when compared to nonhandled weanling rats of nonhandled mothers. Handling of the offspring when they are infants appears to counteract the influence of the experience of the mother during her infancy.

                Author and article information

                Horm Res Paediatr
                Hormone Research in Paediatrics
                S. Karger AG
                April 2006
                10 April 2006
                : 65
                : Suppl 3
                : 70-74
                ‘Rina Balducci’ Centre of Paediatric Endocrinology, Department of Public Health and Cell Biology, Tor Vergata University, Rome, Italy
                91509 Horm Res 2006;65:70–74
                © 2006 S. Karger AG, Basel

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                Page count
                Figures: 3, References: 30, Pages: 5
                Early Postnatal Growth


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