6
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      An Early Postnatal Oxytocin Treatment Prevents Social and Learning Deficits in Adult Mice Deficient for Magel2, a Gene Involved in Prader-Willi Syndrome and Autism.

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Mutations of MAGEL2 have been reported in patients presenting with autism, and loss of MAGEL2 is also associated with Prader-Willi syndrome, a neurodevelopmental genetic disorder. This study aimed to determine the behavioral phenotype of Magel2-deficient adult mice, to characterize the central oxytocin (OT) system of these mutant mice, and to test the curative effect of a peripheral OT treatment just after birth.

          Related collections

          Author and article information

          Journal
          Biol. Psychiatry
          Biological psychiatry
          1873-2402
          0006-3223
          Jul 15 2015
          : 78
          : 2
          Affiliations
          [1 ] Institut de la Clinique de la Souris, Strasbourg.
          [2 ] Institut de Neurobiologie de la Méditerranée; Aix-Marseille Université, Marseille.
          [3 ] Plateforme Protéomique et Innovation Technologique Timone, Marseille.
          [4 ] Institut de Génomique Fonctionnelle, National Centre for Scientific Research, Universités de Montpellier 1 and 2, Montpellier.
          [5 ] Unité d'endocrinologie et Centre de Référence du Syndrome de Prader-Willi (MT), Centre de Physiopathologie de Toulouse-Purpan, Hôpital des enfants, Toulouse, France.
          [6 ] Institut de Neurobiologie de la Méditerranée; Aix-Marseille Université, Marseille. Electronic address: francoise.muscatelli@inserm.fr.
          Article
          S0006-3223(14)00887-7
          10.1016/j.biopsych.2014.11.010
          25599930
          3e3eccef-99c2-494d-8a68-8992ee62090d
          Copyright © 2015 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.

          Autism spectrum disorder,MAGEL2,Neurodevelopment,Oxytocin,Prader-Willi syndrome,Therapy

          Comments

          Comment on this article