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      Outcomes of a novel alloplastic technique for external auditory canal repair in tympanomastoidectomy

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          Abstract

          Objective

          To analyze surgical outcomes of a novel alloplastic reconstruction technique for partial external auditory canal (EAC) defects in tympanomastoidectomy.

          Methods

          Retrospective study of 51 patients with cholesteatoma who underwent repair of partial EAC defects during tympanomastoidectomy at a tertiary referral center over 8 years. Nineteen patients were treated with a novel alloplastic graft technique using hydroxyapatite cement and bone pâté for EAC repair. Thirty‐two patients treated with traditional cartilage repair of the EAC served as a control group. The primary outcomes measured were postoperative cholesteatoma recurrence rates, infection rates, and mean air‐bone gap (ABG).

          Results

          Twenty of the 51 cases (39.2%) were revision surgeries for cholesteatoma recidivism, with a greater proportion of revision surgeries in the alloplastic group (57.9% vs 28.1%, P = .04). There was no significant difference in postoperative cholesteatoma recurrence ( P = 1.00) or infection rates ( P = .64) between the two techniques, with the alloplastic group experiencing slightly lower rates of recurrence (36.8%) and infection (5.3%) than cartilage repair (37.5% recurrence, 12.5% infection). Mean postoperative ABGs were comparable between the alloplastic (21.5 dB) and cartilage group (26.0 dB, P = .10).

          Conclusions

          Composite alloplastic and bone pâté reconstruction is an effective technique to repair partial EAC defects in tympanomastoidectomy, with comparable postoperative hearing outcomes and no increased risk of cholesteatoma recurrence or infection compared to traditional cartilage repair. Recidivism rates were relatively high in both groups, likely due to the high rate of revision surgeries and aggressive nature of cholesteatoma within the cohort.

          Level of Evidence

          Level 3B.

          Abstract

          A retrospective study was performed to evaluate the surgical outcomes of a novel alloplastic technique using hydroxyapatite cement and bone pâté to repair partial external auditory canal (EAC) defects in intact canal wall tympanomastoidectomy. The study demonstrated that this alloplastic technique provides a viable alternative to cartilage repair of the EAC, with comparable outcomes in regard to infection, cholesteatoma recurrence, and hearing results.

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          Most cited references17

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          Hydroxyapatite cement. I. Basic chemistry and histologic properties.

          Hydroxyapatite cement is a unique calcium phosphate preparation that can be shaped intraoperatively and sets in vivo to an implant composed of microporous hydroxyapatite. The histologic response to this cement was evaluated by implanting disks made of this material within the heads of nine cats. Three sets of 12 hydroxyapatite cement disks were produced containing 0%, 10%, and 20% macropores by volume, respectively. The disks were implanted subcutaneously, intramuscularly, above the periosteum of the skull, and directly onto the surface of the calvarium. Each macropore percentage was represented in each tissue plane, and animals were killed up to 9 months postoperatively. There were no toxic reactions, implants extruded, or wound infections. Histologic examination of the implant-soft-tissue interfaces revealed a transient inflammatory response without foreign body reaction. The disks were resorbed over time in direct proportion to their macropore content (surface areas) in all groups except for those disks placed directly onto the surface of the calvarium below the periosteum. In this group, numerous foci of bone formed at the skull-implant interface, with variable replacement of the deep surface of these implants by bone. Implant replacement by bone is postulated to occur through a combination of implant resorption coupled with osteoconduction. Based on these properties, hydroxyapatite cement may prove useful when applied to the reconstruction of non-stress-bearing skeletal tissue.
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            Single-Stage Mastoid Obliteration in Cholesteatoma Surgery and Recurrent and Residual Disease Rates

            The ideal surgical treatment of cholesteatoma has been subject to discussion for years because both traditional surgical techniques (canal wall down [CWD] and canal wall up [CWU] tympanoplasty) have their own advantages and disadvantages. A more recently propagated surgical approach, to combine the CWD or CWU tympanoplasty technique with obliteration of the mastoid and epitympanum, is showing promising results.
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              Mastoid Obliteration with Autologous Bone in Mastoidectomy Canal Wall Down Surgery: a Literature Overview

              Introduction The objectives of mastoidectomy in cholesteatoma are a disease-free and dry ear, the prevention of recurrent disease, and the maintenance of hearing or the possibility to reconstruct an affected hearing mechanism. Canal wall down mastoidectomy has been traditionally used to achieve those goals with greater or lesser degrees of success. However, canal wall down is an aggressive approach, as it involves creating an open cavity and changing the anatomy and physiology of the middle ear and mastoid. A canal wall up technique eliminates the need to destroy the middle ear and mastoid, but is associated with a higher rate of residual cholesteatoma. The obliteration technics arise as an effort to avoid the disadvantages of both techniques. Objectives Evaluate the effectiveness of the mastoid obliteration with autologous bone in mastoidectomy surgery with canal wall down for chronic otitis, with or without cholesteatoma. Data Synthesis We analyzed nine studies of case series comprehending similar surgery techniques on 1017 total cases of operated ears in both adults and children, with at least 12 months follow-up. Conclusion Mastoid Obliteration with autologous bone has been utilized for many years to present date, and it seems to be safe, low-cost, with low recurrence rates - similar to traditional canal wall down procedures and with greater water resistance and quality of life improvements.
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                Author and article information

                Contributors
                james.e.saunders@hitchcock.org
                Journal
                Laryngoscope Investig Otolaryngol
                Laryngoscope Investig Otolaryngol
                10.1002/(ISSN)2378-8038
                LIO2
                Laryngoscope Investigative Otolaryngology
                John Wiley & Sons, Inc. (Hoboken, USA )
                2378-8038
                04 August 2020
                August 2020
                : 5
                : 4 ( doiID: 10.1002/lio2.v5.4 )
                : 743-749
                Affiliations
                [ 1 ] Dartmouth Geisel School of Medicine Hanover New Hampshire USA
                [ 2 ] Dartmouth‐Hitchcock Medical Center Lebanon New Hampshire USA
                Author notes
                [*] [* ] Correspondence

                James E. Saunders, Department of Otolaryngology, Dartmouth‐Hitchcock Medical Center, 1 Medical Center Drive, Lebanon, NH 03756, USA.

                Email: james.e.saunders@ 123456hitchcock.org

                Author information
                https://orcid.org/0000-0003-3156-3212
                https://orcid.org/0000-0003-4588-827X
                https://orcid.org/0000-0003-1896-5348
                Article
                LIO2419
                10.1002/lio2.419
                7444778
                3e4829b8-da08-47b7-a064-a1d78ed233dc
                © 2020 The Authors. Laryngoscope Investigative Otolaryngology published by Wiley Periodicals LLC. on behalf of The Triological Society.

                This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

                History
                : 19 April 2020
                : 26 May 2020
                Page count
                Figures: 2, Tables: 2, Pages: 7, Words: 4395
                Categories
                Original Research
                Otology, Neurotology, and Neuroscience
                Original Research
                Custom metadata
                2.0
                August 2020
                Converter:WILEY_ML3GV2_TO_JATSPMC version:5.8.7 mode:remove_FC converted:24.08.2020

                cholesteatoma,external auditory canal,external ear,otology

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