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Cathepsin S inhibition suppresses systemic lupus erythematosus and lupus nephritis because cathepsin S is essential for MHC class II-mediated CD4 T cell and B cell priming.
Khader Valli Rupanagudi
1 ,
Onkar P Kulkarni
1 ,
Julia Lichtnekert
1 ,
Murthy Narayana Darisipudi
1 ,
Shrikant R Mulay
1 ,
Brigitte Schott
2 ,
Sabine Gruner
2 ,
Wolfgang Haap
2 ,
Guido Hartmann
2 ,
Hans-Joachim Anders
1
Feb 2015
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Abstract
Major histocompatibility complex (MHC) class II-mediated priming of T and B lymphocytes is a central element of autoimmunity in systemic lupus erythematosus (SLE) and lupus nephritis. The cysteine protease cathepsin S degrades the invariant peptide chain during MHC II assembly with antigenic peptide in antigen-presenting cells; therefore, we hypothesised that cathepsin S inhibition would be therapeutic in SLE.