24
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: not found
      • Article: not found

      Th17/Treg imbalance in adult patients with minimal change nephrotic syndrome

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          To determine whether Th17/Treg balance was abnormal in adult patients with minimal change nephrotic syndrome (MCNS), we studied 25 patients with new-onset MCNS and 20 normal persons. The results showed that MCNS patients exhibited a significant increase in Th17 number, Th17-related cytokines (IL-17 and IL-23), and transcription factor (RORγt) levels, as well as an obvious decrease in Treg number, Treg-related cytokines (TGF-β1 and IL-10), and transcription factor (Foxp3) levels. The Th17/Treg ratios increased along with increased proteinuria and decreased albumin levels in patients with MCNS. IL-17 protein expression was also detected in the renal biopsy tissue of MCNS patients, particularly in patients with acute renal failure. Further, Th17/Treg balance returned to normal after effective corticosteroids therapy in 16 MCNS patients. These results indicated that Th17/Treg imbalance existed in MCNS patients, suggesting a potential role of Th17/Treg imbalance in the pathogenesis of MCNS. Copyright © 2011 Elsevier Inc. All rights reserved.

          Related collections

          Author and article information

          Journal
          Clinical Immunology
          Clinical Immunology
          Elsevier BV
          15216616
          June 2011
          June 2011
          : 139
          : 3
          : 314-320
          Article
          10.1016/j.clim.2011.02.018
          21450528
          3e6ce4db-cca6-4ef8-9047-1252a260daff
          © 2011

          https://www.elsevier.com/tdm/userlicense/1.0/

          History

          Comments

          Comment on this article