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      The role of autophagy in modulation of neuroinflammation in microglia.

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          Abstract

          Microglia have multiple functions in regulating homeostasis in the central nervous system (CNS), and microglial inflammation is thought to play a role in the etiology of the neurodegenerative diseases. When endogenous or exogenous stimuli trigger disorders in microenvironmental homeostasis in CNS, microglia critically determine the fate of other neural cells. Recently, it was reported that autophagy might influence inflammation and activation of microglia. Though the interaction between autophagy and macrophages has been reported and reviewed in length, the role of autophagy in microglia has yet to be reviewed. Herein, we will highlight recent advances on the emerging role of autophagy in microglia, focusing on the regulation of autophagy during microglial inflammation, and the possible mechanism involved.

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          Author and article information

          Journal
          Neuroscience
          Neuroscience
          1873-7544
          0306-4522
          Apr 5 2016
          : 319
          Affiliations
          [1 ] Department of Occupational & Environmental Health and the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, Fourth Military Medical University, Xi'an 710032, China.
          [2 ] Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, United States.
          [3 ] Department of Occupational & Environmental Health and the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, Fourth Military Medical University, Xi'an 710032, China. Electronic address: luowenj@fmmu.edu.cn.
          Article
          S0306-4522(16)00063-4
          10.1016/j.neuroscience.2016.01.035
          26827945
          3e753ab3-bada-40cd-9a86-02af5be1a646
          Copyright © 2016 IBRO. Published by Elsevier Ltd. All rights reserved.
          History

          autophagy,inflammation,microglia
          autophagy, inflammation, microglia

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