Uremia and Hypoxia Independently Induce Eryptosis and Erythrocyte Redox Imbalance.

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Abstract

Red blood cell (RBC) death could contribute to anemia in chronic kidney disease (CKD) patients. Recent observational research has suggested a relationship between RBC death (eryptosis) and hypoxemia in hemodialysis patients. Thus, we studied the isolated and joint effects of a uremic toxin (indoxyl sulfate; IS) and hypoxia on RBC biology.

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Journal

Journal ID (iso-abbrev): Cell. Physiol. Biochem.

Title: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

Publisher: Cell Physiol Biochem Press GmbH and Co KG

ISSN (Electronic): 1421-9778

ISSN (Print): 1015-8987

Publication date (Electronic): 2019

Volume: 53

Affiliations

[1 ] Pontifícia Universidade Católica do Paraná (PUCPR), PPGCS, Paraná, Brazil.

[2 ] Renal Research Institute, New York, NY, USA.

[3 ] Icahn School of Medicine at Mount Sinai, New York, NY, USA.

[4 ] Pontifícia Universidade Católica do Paraná (PUCPR), PPGCS, Paraná, Brazil, andrea.moreno@pucr.br.

Article

DOI: 10.33594/000000173

PubMed ID: 31661199

SO-VID: 3e757bc9-d4c5-4fd5-aed9-985d4b9957e0

History

Keywords: Indoxyl sulfate; Eryptosis; Hypoxia; ROS; Glutathione; Uremia

Data availability:

Keywords: Indoxyl sulfate; Eryptosis; Hypoxia; ROS; Glutathione; Uremia

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