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      Mesothelium expression of vascular cell adhesion molecule-1 (VCAM-1) is associated with an unfavorable prognosis in epithelial ovarian cancer (EOC).

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          Abstract

          Mesothelium vascular cell adhesion molecule-1 (VCAM-1) expression in the metastatic epithelial ovarian cancer (EOC) microenvironment is induced by tumor and mediates tumor cell invasion. VCAM-1 imaging suggests expression during treatment is an indicator of platinum resistance. Here, we assess the potential prognostic significance of mesothelium VCAM-1 expression and prospectively evaluate whether soluble VCAM-1 (sVCAM-1) is a surrogate for mesothelium expression.

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          Author and article information

          Journal
          Cancer
          Cancer
          Wiley-Blackwell
          1097-0142
          0008-543X
          May 15 2017
          : 123
          : 6
          Affiliations
          [1 ] Department of Obstetrics and Gynecology, University of Virginia, Charlottesville, Virginia.
          [2 ] Department of Pathology, University of Virginia, Charlottesville, Virginia.
          [3 ] Cancer Center, University of Virginia, Charlottesville, Virginia.
          [4 ] Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia.
          [5 ] Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, Virginia.
          Article
          NIHMS822356
          10.1002/cncr.30415
          5341143
          28263384

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