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      Acute toxicity related to misuse (nonmedical use) of tramadol: Experience of the European Drug Emergencies Network Plus.

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          Abstract

          Following the development of the tramadol crisis currently affecting countries in the Middle East, and Africa, there has been increasing international interest in the regulation of tramadol. This study investigates the misuse of tramadol in patients presenting to emergency departments across Europe. Data from 32 emergency departments in 21 countries were extracted from the Euro-DEN Plus database for the 4-year period from 1 January 2014 to 31 December 2017. Of the reported 24,957 emergency department presentations, tramadol misuse was reported in 105 (0.4% presentations). Tramadol misuse was most common in Bratislava (Slovakia; n = 11, 7.5% of all presentations to this centre), Riga (Latvia; n = 4, 4.9%) and Munich (Germany; n = 17, 2.9%). On arrival, 14 (13.3%) of presentations were in coma/Glasgow coma score ≤ 8 and 9 of these had a respiratory rate <12 breaths/min. These presentations potentially pose a significant burden on emergency departments with a large proportion requiring admission to hospital for ongoing care.

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          Author and article information

          Journal
          Br J Clin Pharmacol
          British journal of clinical pharmacology
          Wiley
          1365-2125
          0306-5251
          Apr 2021
          : 87
          : 4
          Affiliations
          [1 ] Clinical Toxicology, Guy's and St Thomas' NHS Foundation Trust, UK.
          [2 ] Clinical Toxicology, Guy's and St Thomas' NHS Foundation Trust and King's Health Partners, London, UK.
          [3 ] Clinical Toxicology, Faculty of Life Sciences and Medicine, King's College London, London, UK.
          [4 ] Emergency Department and Clinical Toxicology Unit, Hospital Universitari Son Espases, Mallorca, Spain.
          [5 ] The Norwegian CBRNe Centre of Medicine, Oslo University Hospital, Oslo, Norway.
          [6 ] Prehospital Division, Oslo University Hospital, Oslo, Norway.
          [7 ] The Norwegian Air Ambulance Foundation, Oslo, Norway.
          [8 ] European Monitoring Centre for Drugs and Drug Addiction (EMCDDA), Lisbon, Portugal.
          Article
          10.1111/bcp.14408
          32503085
          3ea7c654-d546-4863-b3d4-f6f384b02050
          History

          recreational,toxicology,tramadol,opioid
          recreational, toxicology, tramadol, opioid

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