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      Th1/Th2/Th17 and regulatory T-cell paradigm in pregnancy.

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          Abstract

          T-helper (Th) cells play a central role in modulating immune responses. The Th1/Th2 paradigm has now developed into the new Th1/Th2/Th17 paradigm. In addition to effector cells, Th cells are regulated by regulatory T (Treg) cells. Their capacity to produce cytokines is suppressed by immunoregulatory cytokines such as transforming growth factor (TGF)-beta and interleukin (IL)-10 or by cell-to-cell interaction. Here, we will review the immunological environment in normal pregnancy and complicated pregnancy, such as implantation failure, abortion, preterm labor, and preeclampsia from the viewpoint of the new Th1/Th2/Th17 and Treg paradigms.

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          Author and article information

          Journal
          Am J Reprod Immunol
          American journal of reproductive immunology (New York, N.Y. : 1989)
          Wiley
          1600-0897
          1046-7408
          Jun 2010
          : 63
          : 6
          Affiliations
          [1 ] Department of Obstetrics and Gynecology, University of Toyama, Toyama, Japan. s30saito@med.u-toyama.ac.jp
          Article
          AJI852
          10.1111/j.1600-0897.2010.00852.x
          20455873
          41f797a2-d444-4dc1-aed8-07957d7fadde

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