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      Clinical Profile and Influences on Outcomes in Patients Hospitalized for Acute Pericarditis

      Author(s): 1 , 1 , 1
      Publication date Created:
      Publication date (Print):
      Journal: Circulation
      Publisher: Ovid Technologies (Wolters Kluwer Health)

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          Abstract

          The clinical profile with regard to sex and the influences on outcomes in patients who have been hospitalized for acute pericarditis is largely uncharacterized.

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          A randomized trial of colchicine for acute pericarditis.

          Massimo Imazio, Antonio Brucato, Roberto Cemin … (2013)
          Colchicine is effective for the treatment of recurrent pericarditis. However, conclusive data are lacking regarding the use of colchicine during a first attack of acute pericarditis and in the prevention of recurrent symptoms.
          Article 0 comments Cited 114 times – based on 0 reviews     Review now
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            Colchicine in addition to conventional therapy for acute pericarditis: results of the COlchicine for acute PEricarditis (COPE) trial.

            Massimo Imazio, Marco Bobbio, Enrico Cecchi … (2005)
            Colchicine is effective and safe for the treatment and prevention of recurrent pericarditis and might ultimately serve as the initial mode of treatment, especially in idiopathic cases. The aim of this work was to verify the safety and efficacy of colchicine as an adjunct to conventional therapy for the treatment of the first episode of acute pericarditis. A prospective, randomized, open-label design was used. A total of 120 patients (mean age 56.9+/-18.8 years, 54 males) with a first episode of acute pericarditis (idiopathic, viral, postpericardiotomy syndromes, and connective tissue diseases) were randomly assigned to conventional treatment with aspirin (group I) or conventional treatment plus colchicine 1.0 to 2.0 mg for the first day and then 0.5 to 1.0 mg/d for 3 months (group II). Corticosteroid therapy was restricted to patients with aspirin contraindications or intolerance. The primary end point was recurrence rate. During the 2873 patient-month follow-up, colchicine significantly reduced the recurrence rate (recurrence rates at 18 months were, respectively, 10.7% versus 32.3%; P=0.004; number needed to treat=5) and symptom persistence at 72 hours (respectively, 11.7% versus 36.7%; P=0.003). After multivariate analysis, corticosteroid use (OR 4.30, 95% CI 1.21 to 15.25; P=0.024) was an independent risk factor for recurrences. Colchicine was discontinued in 5 cases (8.3%) because of diarrhea. No serious adverse effects were observed. Colchicine plus conventional therapy led to a clinically important and statistically significant benefit over conventional treatment, decreasing the recurrence rate in patients with a first episode of acute pericarditis. Corticosteroid therapy given in the index attack can favor the occurrence of recurrences.
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              Controversial issues in the management of pericardial diseases.

              David Spodick, Rita Trinchero, Yehuda Adler … (2010)
              Article 0 comments Cited 70 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Title: Circulation
                Abbreviated Title: Circulation
                Publisher: Ovid Technologies (Wolters Kluwer Health)
                ISSN (Print): 0009-7322
                ISSN (Electronic): 1524-4539
                Publication date Created: October 28 2014
                Publication date (Print): October 28 2014
                Volume: 130
                Issue: 18
                Pages: 1601-1606
                Affiliations
                [1 ]From the Heart Center, (V.K.), Clinical Neurosciences, Neurology (J.S.), and Clinical Research Center (P.R.), Turku University Hospital, and PET Center (V.K.), Neurology (J.S.), and Public Health (P.R.), University of Turku, Turku, Finland.
                Article
                DOI: 10.1161/CIRCULATIONAHA.114.010376
                PubMed ID: 25205801
                SO-VID: 3ebb1810-d59a-4b6a-aa28-aa01a95b064a
                Copyright © © 2014
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