There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
Abstract
In a double-blind controlled clinical study, 71 patients with recurrent calcium oxalate
stones were divided into three treatment groups: those who received potassium acid
phosphate, those who received an inert placebo, and those who received a low calcium
diet only. Follow-up periods averaged 2.9 years. Although the mean urinary calcium
level of the patients who received phosphate was reduced 33 per cent, their renal
stone disease did not diminish. Mean urinary phosphorus increased 88 per cent with
phosphate treatment but did not correlate with the decrease in urinary calcium, or
with treatment success. The data did not suggest that phosphorus and its metabolites
retard calcium oxalate crystallization in urine. No evidence appeared for an association
of hypercalciuria with severe stone disease, or with a specific clinical or chemical
response to phosphate therapy. Patients whose urinary calcium level fell more than
25 percent when dietary calcium was reduced may have excessive gastrointestinal calcium
absorption, which appears to be associated with improved chemical response to phosphate
therapy.