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      Mechanistic biological modeling thrives

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      Science

      American Association for the Advancement of Science (AAAS)

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          Most cited references 2

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          Assembly mechanism of the contractile ring for cytokinesis by fission yeast.

          Animals and fungi assemble a contractile ring of actin filaments and the motor protein myosin to separate into individual daughter cells during cytokinesis. We used fluorescence microscopy of live fission yeast cells to observe that membrane-bound nodes containing myosin were broadly distributed around the cell equator and assembled into a contractile ring through stochastic motions, after a meshwork of dynamic actin filaments appeared. Analysis of node motions and numerical simulations supported a mechanism whereby transient connections are established when myosins in one node capture and exert force on actin filaments growing from other nodes.
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            Is Open Access

            Sequences and consequences

            The conversion of data into knowledge constitutes a great challenge for future biological research. The new science of Systems Biology claims to be able to solve the problem but I contend that this approach will fail because deducing models of function from the behaviour of a complex system is an inverse problem that is impossible to solve. In addition, one cannot easily escape into high-level holistic approaches, since the essence of all biological systems is that they are encoded as molecular descriptions in their genes and since genes are molecules and exert their functions through other molecules, the molecular explanation must constitute the core of understanding biological systems. We then solve the forward problem of computing the behaviour of the system from its components and their interactions. I propose that the correct level of abstraction is the cell and provide an outline of Cellmap, a design for a system to organize biological information.
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              Author and article information

              Journal
              Science
              Science
              American Association for the Advancement of Science (AAAS)
              0036-8075
              1095-9203
              January 14 2016
              January 15 2016
              January 14 2016
              January 15 2016
              : 351
              : 6270
              : 234-235
              Article
              10.1126/science.351.6270.234-c
              © 2016

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