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      Progression of Chronic Renal Failure in a Rat Strain with Autosomal Dominant Polycystic Kidney Disease


      S. Karger AG

      Blood pressure, Chronic renal failure, progression, Lipids, Proteinuria, Unilateral nephrectomy

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          Recently, the existence of a rat strain exhibiting autosomal dominant polycystic kidney disease (PKD) resembling human PKD has been described. An exact description of the course of chronic renal failure in this strain, however, is still missing. Thus the aim of this study was to analyze the long-term course of renal failure in these rats. In addition, unilateral nephrectomy (UNX) was performed in order to evaluate the impact of UNX on the occurrence of uremia. Our data clearly revealed that 70-80% of all animals of this rat strain developed uremia within 21 months. Additionally, proteinuria and hypercholesterolemia occurred, while the blood pressure was fairly unaffected. Also a slight degree of anemia was noted. In this long-term study death was due to uremia. The median survival time was significantly shorter in UNX PKD (median 11.6 months) than in non-UNX PKD animals (17.0 months; log-rank test: p = 0.001). In conclusion: with respect to renal function this rat model resembles human PKD disease. Furthermore, we could demonstrate that UNX is suitable to accelerate the rate of progression of renal failure in this model.

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          Author and article information

          S. Karger AG
          17 December 2008
          : 68
          : 4
          : 462-467
          Division of Nephrology, University of Heidelberg, Klinikum Mannheim, Germany
          188308 Nephron 1994;68:462–467
          © 1994 S. Karger AG, Basel

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          Pages: 6
          Original Paper


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