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      Strengthened thalamoparietal functional connectivity in patients with hemifacial spasm: a cross-sectional resting-state fMRI study

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          Abstract

          Objective:

          In spite of the well-known importance of thalamus in hemifacial spasm (HFS), the thalamic resting-state networks in HFS is still rarely mentioned. This study aimed to investigate resting-state functional connectivity (FC) of the thalamus in HFS patients and examine its association with clinical measures.

          Methods:

          25 HFS patients and 28 matched healthy controls underwent functional MRI at rest. Using the left and right thalamus as seed regions respectively, we compared the thalamic resting-state networks between patient and control groups using two independent sample t-test.

          Results:

          Compared with controls, HFS patients exhibited strengthened bilateral thalamus-seeded FC with the parietal cortex. Enhanced FC between right thalamus and left somatosensory association cortex was linked to worse motor disturbance, and the increased right thalamus-right supramarginal gyrus connection were correlated with improvement of affective symptoms.

          Conclusion:

          Our findings indicate that the right thalamus–left somatosensory association cortex hyperconnectivity may represent the underlying neuroplasticity related to sensorimotor dysfunction. In addition, the upregulated FC between the right thalamus and right supramarginal gyrus in HFS, is part of the thalamo-default mode network pathway involved in emotional adaptation.

          Advances in knowledge:

          This study provides new insights on the integrative role of thalamo-parietal connectivity, which participates in differential neural circuitry as a mechanism underlying motor and emotional functions in HFS patients.

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          Author and article information

          Contributors
          Journal
          Br J Radiol
          Br J Radiol
          bjr
          The British Journal of Radiology
          The British Institute of Radiology.
          0007-1285
          1748-880X
          March 2020
          19 March 2020
          : 93
          : 1108
          Affiliations
          [1 ] org-divisionDepartment of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University , Xi'an 710061, PR China
          [2 ] org-divisionKey Laboratory of Biomedical Information Engineering of Education Ministry, Institute of Biomedical Engineering, Xi’an Jiaotong University , Xi'an 710049, PR China
          [3 ] org-divisionWashington University School of Medicine , St. Louis, MO 63110, USA
          Author notes
          Address correspondence to: Ming Zhang. E-mail: zmmri@ 123456163.com
          Address correspondence to: Dr Yuan Wang. E-mail: wangyuan8003@ 123456126.com
          Article
          PMC7362923 PMC7362923 7362923 BJR-D-19-00887
          10.1259/bjr.20190887
          7362923
          31904268
          3f00ee99-cc6a-4114-8e23-c1757fba97e0
          © 2020 The Authors. Published by the British Institute of Radiology
          Page count
          Figures: 2, Tables: 2, Equations: 0, References: 42, Pages: 0, Words: 5263
          Categories
          Full Paper
          bjr, BJR
          neuro, Neuroradiology
          h-n, Head and neck

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