Inhibition of neuronal activity of the substantia nigra by noxious stimuli and its modification by the caudate nucleus

Abstract

In urethane-anesthetized rats discharges of neurons of substantia nigra, pars compacta (SNC) were recorded extracellularly after natural somatic sensory stimulation and electrical stimulation of peripheral sensory nerves. (1) Among different modalities of somatic sensory stimulation tested, noxious stimuli were effective in reducing spontaneous discharges of SNC neurons. The inhibition appeared with a concomitant increase of spike amplitude. The same inhibitory effect was obtained by stimulating the sciatic nerve (SC) repetitively. In response to single shock stimulation of the SC the inhibition occurred at an average latency of 39.6 msec (S.E. 1.6 msec) and lasted for 221.6 msec on average (S.E. 10.8 msec). (2) The SC-induced inhibition of SNC neurons failed to reliably block ortho- and antidromic discharges evoked from the caudate nucleus (Cd). (3) In rats with the Cd lesioned the SC-induced inhibition was longer lasting than in controls. When the Cd was stimulated concurrently with SC stimulation, the inhibition from the SC was weakened. (4) In a majority of SNC neurons, their inhibition by SC stimulation, their inhibition by SC stimulation was antagonized by intravenous injection of haloperidol.