138
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Elevation of total homocysteine levels in patients with Parkinson's disease treated with duodenal levodopa/carbidopa gel.

      Journal of Neural Transmission

      Aged, Antiparkinson Agents, administration & dosage, adverse effects, Carbidopa, blood, Drug Combinations, Duodenum, Female, Gels, Homocysteine, biosynthesis, Humans, Hyperhomocysteinemia, chemically induced, Levodopa, Male, Methyldopa, Middle Aged, Parkinson Disease, drug therapy

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Levodopa/carbidopa (LD/CD) application elevates total plasma homocysteine (thcys). We determined thcys-, LD- and 3-O-methyldopa (3-OMD) concentrations in 28 patients with Parkinson's disease (PD) on a LD/CD duodenal gel treatment. We found a distinct thcys increase (29.52 ± 28.98 μmol/l [median ± SD]) above the 15 μmol/l threshold and a significant (R = 0.7) correlation between LD and 3-OMD. thcys ascent was observed in relation with the onset of atherosclerosis, non-motor symptoms and polyneuropathy in PD patients in the long term.

          Related collections

          Author and article information

          Journal
          21359971
          10.1007/s00702-011-0614-9

          Comments

          Comment on this article