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      Use of radiation therapy in posttransplant lymphoproliferative disorder (PTLD) after liver transplantation.

      International Journal of Cancer. Journal International du Cancer

      Algorithms, Cyclosporine, adverse effects, Epstein-Barr Virus Infections, Female, Graft Rejection, prevention & control, Hepatitis C, Humans, Immunosuppression, Immunosuppressive Agents, Liver Cirrhosis, surgery, virology, Liver Transplantation, Lymphoma, B-Cell, radiotherapy, Lymphoproliferative Disorders, etiology, Middle Aged, Prednisone, Tomography, X-Ray Computed

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          Abstract

          Posttransplant lymphoproliferative disorder (PTLD) is a common and life-threatening complication of immunosuppression used to prevent rejection of solid organ and bone marrow transplants. There is no standardized treatment algorithm, but numerous management strategies are available. We describe a patient who developed a solitary lymphoproliferative lesion in the porta hepatis 9 months after orthotopic liver transplant. Following reduction in immunosuppression with no response, she was treated with involved field radiotherapy utilizing CT-based treatment planning. A partial radiographic response was obtained, and she has not developed disease in the engrafted liver or systemically. Based on the present case report, involved field radiotherapy seems to be a reasonable treatment option for patients with localized PTLD. Int. J. Cancer (Radiat. Oncol. Invest.) 90:104-109, 2000. Copyright 2000 Wiley-Liss, Inc.

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